Hermann Bruce, Seidenberg Michael, Lee Eun-Jeong, Chan Fong, Rutecki Paul
Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA.
J Int Neuropsychol Soc. 2007 Jan;13(1):12-20. doi: 10.1017/S135561770707004X.
The objective of this study is to determine if distinct cognitive phenotypes could be identified in temporal lobe epilepsy. Epilepsy patients (n = 96) and healthy controls (n = 82) underwent comprehensive neuropsychological assessment. Adjusted (age, gender, and education) test scores for epilepsy subjects were grouped into cognitive domains (intelligence, language, visuoperception, immediate and delayed memory, executive function, and cognitive/psychomotor speed). Cluster analysis revealed three distinct cognitive profiles types: (1) minimally impaired (47% of subjects); (2) memory impaired (24%); and (3) memory, executive, and speed impaired (29%). The three cluster groups exhibited different patterns of results on demographic, clinical epilepsy, brain volumetrics, and cognitive course over a 4-year interval. The specific profile characteristics of the identified cognitive phenotypes are presented and their implications for the investigation of the neurobehavioral complications of epilepsy are discussed.
本研究的目的是确定在颞叶癫痫中是否可以识别出不同的认知表型。癫痫患者（n = 96）和健康对照者（n = 82）接受了全面的神经心理学评估。癫痫受试者经调整（年龄、性别和教育程度）后的测试分数被分组到认知领域（智力、语言、视觉感知、即时和延迟记忆、执行功能以及认知/心理运动速度）。聚类分析揭示了三种不同的认知概况类型：（1）轻度受损（47%的受试者）；（2）记忆受损（24%）；以及（3）记忆、执行功能和速度受损（29%）。这三个聚类组在人口统计学、临床癫痫、脑容量测量以及4年期间的认知过程方面呈现出不同的结果模式。本文呈现了所识别出的认知表型的具体概况特征，并讨论了它们对癫痫神经行为并发症研究的意义。
