Polge Cécile, Thomas Martine
Laboratoire Physiologie Cellulaire Végétale, UMR5168, CEA/ Université Joseph Fourier, F-38054 Grenoble, France.
Trends Plant Sci. 2007 Jan;12(1):20-8. doi: 10.1016/j.tplants.2006.11.005. Epub 2006 Dec 12.
The SNF1-related kinases are considered to be crucial elements of transcriptional, metabolic and developmental regulation in response to stress. In yeast, SNF1 is one of the main regulators in the shift from fermentation to aerobic metabolism; AMPK, its mammalian counterpart, is a master metabolic regulator involved in a variety of metabolic disorders such as diabetes and obesity. The aim of this review is to examine the literature concerning SnRK1 proteins, the SNF1 homologues in plants. The remarkable structural similarities between the plant complexes and those of yeast and mammalian suggest the existence of a common ancestral function in the regulation of energy and carbon metabolism. We will also highlight some distinctive features acquired by the plant proteins during evolution.
SNF1相关激酶被认为是应激反应中转录、代谢和发育调控的关键元件。在酵母中，SNF1是从发酵代谢转变为有氧代谢的主要调节因子之一；其在哺乳动物中的对应物AMPK是一种主要的代谢调节因子，参与糖尿病和肥胖等多种代谢紊乱。本综述的目的是研究有关植物中SNF1同源物SnRK1蛋白的文献。植物复合物与酵母和哺乳动物复合物之间显著的结构相似性表明，在能量和碳代谢调控方面存在共同的祖先功能。我们还将强调植物蛋白在进化过程中获得的一些独特特征。
