Forte R, Pascotto F, Cennamo G, de Crecchio G
Eye Department, University Federico II, Naples, Italy.
Eye (Lond). 2008 Jan;22(1):158-61. doi: 10.1038/sj.eye.6702666. Epub 2006 Dec 15.
A newly recognized lesion in pathologic myopia is peripapillary detachment of the retinal pigment epithelium (RPE) and retina. Recently introduced en face optical coherence tomography (OCT) provides not only cross-sectional but also coronal scans of the retina, and allows lateral extent visualization and thickness measurement of lesions.
Three patients presenting bilateral peripapillary yellow-orange lobulated area in high myopia have been evaluated with fluorescein angiography (FA), indocyanine green angiography (ICGA), en face OCT (OCT/SLO; Ophthalmic Technologies Inc, Toronto, Canada), and Humphrey visual field analyzer.
In all eyes, en face OCT has shown the presence of a peripapillary sub-RPE nonreflective area. The lateral extent of this area was clearly detectable and the measurement of its thickness was obtained. We detected a cleft in the RPE at one edge of the cavitation in two eyes, vascular tractions and vitreoretinal tractions in two eyes, a macular hole with posterior retinal detachment, and small areas of RPE detachment nonconnected with the peripapillary detachment in one eye. In the four eyes presenting a proper central fixation, glaucomatous visual field defects were evident.
En face OCT has allowed to evaluate the thickness and the lateral extent of the peripapillary detachment. Therefore, its use could be important in determining the size and grading of these lesions at first visit, and to detect minimal changes of width and thickness during follow-up as an alternative to fluorescein angiography.
病理性近视中一种新发现的病变是视网膜色素上皮(RPE)和视网膜的视乳头周围脱离。最近引入的表面光学相干断层扫描(OCT)不仅能提供视网膜的横断面扫描,还能提供冠状面扫描,并能显示病变的横向范围和测量其厚度。
对3例高度近视患者双侧视乳头周围出现黄橙色分叶状区域的情况进行了荧光素血管造影(FA)、吲哚菁绿血管造影(ICGA)、表面OCT(OCT/SLO;加拿大安大略省多伦多市眼科技术公司)和Humphrey视野分析仪检查。
在所有眼中,表面OCT均显示视乳头周围RPE下存在无反射区。该区域的横向范围清晰可测,并测量了其厚度。我们在2只眼中的空洞边缘处检测到RPE层裂孔,2只眼中存在血管牵拉和玻璃体视网膜牵拉,1只眼中有黄斑裂孔伴视网膜后脱离,以及1只眼中有与视乳头周围脱离不相连的小面积RPE脱离。在4只具有正常中心注视的眼中,青光眼性视野缺损明显。
表面OCT能够评估视乳头周围脱离的厚度和横向范围。因此,在首次就诊时使用它对于确定这些病变的大小和分级很重要,并且在随访期间作为荧光素血管造影的替代方法来检测宽度和厚度的微小变化。