Gekeler Florian, Gmeiner Helmut, Völker Michael, Sachs Helmut, Messias Andre, Eule Corinna, Bartz-Schmidt Karl Ulrich, Zrenner Eberhart, Shinoda Kei
University Eye Hospital, Schleichstrasse 12-16, D-72076 Tübingen, Germany.
Vet Ophthalmol. 2007 May-Jun;10(3):173-8. doi: 10.1111/j.1463-5224.2007.00532.x.
To assess the feasibility of optical coherence tomography (OCT) for examining the cat ocular fundus, to provide normative data on retinal thickness in different fundus regions, and to demonstrate selected surgically induced vitreoretinal pathologies in the cat.
Forty-five eyes of 28 healthy domestic cats and two eyes of domestic cats that had undergone subretinal implantation surgery for a visual prosthesis were examined.
An optical coherence tomograph (Zeiss-Humphrey) was used to examine the anesthetized animals. At least five vertical and five horizontal scans in regular distribution were recorded for each cat including (1) the peripapillary region, (2) the area centralis, and (3) the peripheral retina. Thickness was measured manually at five locations in each scan. Retinal thickness was compared in the three above-mentioned fundus regions, between eyes and between vertical and horizontal scans. OCT was additionally performed in animals with retinal detachment and a subretinal visual prosthesis.
OCT measurements required only minimal adjustments of human settings and yielded high quality images. In comparison to humans intraretinal layers were more difficult to differentiate. Retinal thickness was highest in the peripapillary region (245 +/- 21 microm), followed by the peripheral retina (204 +/- 11 microm) and the area centralis (182 +/- 11 microm; all P < 0.0001). There was no statistically significant difference between right and left eye or between vertical and horizontal scans. OCT demonstrated retinal detachment, an iatrogenic break and a subretinal prosthetic device in high detail.
Retinal thickness was measurable with high precision; values compare well to older histologic studies. OCT bears significant advantages over histology in enabling one to repeat measurements in living animals and thus allowing longitudinal studies. Various vitreoretinal pathologies common in feline eyes are detectable and quantifiable by OCT.
评估光学相干断层扫描（OCT）检查猫眼底的可行性，提供不同眼底区域视网膜厚度的规范数据，并展示猫中选定的手术诱发的玻璃体视网膜病变。
对28只健康家猫的45只眼和2只接受视觉假体视网膜下植入手术的家猫的眼睛进行了检查。
使用光学相干断层扫描仪（蔡司 - 汉弗莱）检查麻醉后的动物。为每只猫记录至少5次规则分布的垂直和5次水平扫描，包括（1）视乳头周围区域，（2）中央凹区域，以及（3）周边视网膜。在每次扫描的5个位置手动测量厚度。比较上述三个眼底区域、双眼之间以及垂直和水平扫描之间的视网膜厚度。对患有视网膜脱离和视网膜下视觉假体的动物额外进行了OCT检查。
OCT测量仅需对人体设置进行最小调整，并产生高质量图像。与人类相比，视网膜内层更难区分。视网膜厚度在视乳头周围区域最高（245±21微米），其次是周边视网膜（204±11微米）和中央凹区域（182±11微米；所有P<0.0001）。右眼和左眼之间或垂直和水平扫描之间没有统计学上的显著差异。OCT能够非常详细地显示视网膜脱离、医源性裂孔和视网膜下假体装置。
视网膜厚度可高精度测量；这些值与早期的组织学研究结果相当。OCT在能够对活体动物重复测量从而允许进行纵向研究方面比组织学具有显著优势。OCT可检测和量化猫眼中常见的各种玻璃体视网膜病变。
