来自台湾海桐的细胞毒性法尼基糖苷。
Cytotoxic farnesyl glycosides from Pittosporum pancheri.
作者信息
Eparvier Véronique, Thoison Odile, Bousserouel Hadjira, Guéritte Françoise, Sévenet Thierry, Litaudon Marc
机构信息
Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
出版信息
Phytochemistry. 2007 Mar;68(5):604-8. doi: 10.1016/j.phytochem.2006.11.008. Epub 2006 Dec 18.
Bioassay guided purification of the ethanolic extract of the bark of New Caledonian Pittosporum pancheri Brongn. and Gris (Pittosporaceae) led to the isolation and characterization of two new farnesyl monoglycosides, pancherins A and B. The structure of these compounds were determined on the basis of spectroscopic studies. The new compounds displayed a significant activity in the in vitro cytotoxic assay against KB cancer cell line, and pancherin A inhibits weakly farnesyl protein transferase.
通过生物测定指导，对新喀里多尼亚海桐花（Pittosporum pancheri Brongn. and Gris，海桐花科）树皮的乙醇提取物进行纯化，从而分离并鉴定出两种新的法尼基单糖苷，即海桐花素A和海桐花素B。这些化合物的结构是通过光谱研究确定的。新化合物在针对KB癌细胞系的体外细胞毒性试验中表现出显著活性，并且海桐花素A对法尼基蛋白转移酶有微弱的抑制作用。
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