Riley Anne W, Spiel Georg, Coghill David, Döpfner Manfred, Falissard Bruno, Lorenzo Maria J, Preuss Ulrich, Ralston Stephen J
Johns Hopkins Bloomberg School of Public Health, 692 Hampton House, 624 North Broadway, Baltimore, MD 21205, USA.
Eur Child Adolesc Psychiatry. 2006 Dec;15 Suppl 1:I38-45. doi: 10.1007/s00787-006-1006-9.
To describe the associations between a range of baseline factors (demographic, family and clinical) and parent-reported health-related quality of life (HRQoL) of children with ADHD taking part in the ADORE study.
HRQoL was rated using the Parent Report Form of the Child Health and Illness Profile-Child Edition (CHIP-CE). Forward-stepwise linear regression models were used to investigate associations with 26 independent variables. Separate models were fitted for each of the five CHIP-CE domains (Satisfaction, Comfort, Resilience, Risk Avoidance and Achievement) and two subdomains of Achievement (Academic Performance and Peer Relations).
CHIP-CE domain mean scores were lower than community norms, especially for Risk Avoidance and Achievement, indicating a low level of HRQoL. Clinical factors significantly associated with a poorer HRQoL included ADHD symptoms (inattention, hyperactivity-impulsivity), conduct problems, peer relationship problems, having asthma, multiple other somatic symptoms and co-ordination problems. Family factors, such as having a parent with a health or mental health problem possibly caused by the child's illness, child not living with both parents and maternal smoking during pregnancy were also associated with a worse HRQoL in some CHIP-CE domains/subdomains.
Numerous factors independently impact on the HRQoL of children with ADHD.
描述参加ADORE研究的多动症儿童的一系列基线因素（人口统计学、家庭和临床因素）与家长报告的健康相关生活质量（HRQoL）之间的关联。
使用儿童健康与疾病概况-儿童版（CHIP-CE）的家长报告表对HRQoL进行评分。采用向前逐步线性回归模型研究与26个自变量的关联。针对CHIP-CE的五个领域（满意度、舒适度、恢复力、风险规避和成就）以及成就领域的两个子领域（学业成绩和同伴关系）分别拟合模型。
CHIP-CE领域的平均得分低于社区常模，尤其是风险规避和成就领域，表明HRQoL水平较低。与较差的HRQoL显著相关的临床因素包括多动症症状（注意力不集中、多动-冲动）、品行问题、同伴关系问题、患有哮喘、多种其他躯体症状和协调问题。家庭因素，如父母一方可能因孩子患病而出现健康或心理健康问题、孩子未与父母双方同住以及母亲孕期吸烟，在某些CHIP-CE领域/子领域也与较差的HRQoL相关。
众多因素独立影响多动症儿童的HRQoL。
