Chiquet-Ehrismann R
Friedrich Miescher Institute, Basel, Switzerland.
Curr Opin Cell Biol. 1991 Oct;3(5):800-4. doi: 10.1016/0955-0674(91)90053-2.
The prototype extracellular matrix glycoproteins had been identified on the basis of their activity in promoting cell adhesion and spreading. Recently, more and more evidence is accumulating that the reverse effect of extracellular matrix proteins, namely the inhibition of cell adhesion and spreading, may be equally important for proper cell function during morphogenesis and development. Several anti-adhesive proteins have been described and their mechanisms of action are being investigated.
原型细胞外基质糖蛋白是根据其促进细胞黏附和铺展的活性而被鉴定出来的。最近，越来越多的证据表明，细胞外基质蛋白的相反作用，即抑制细胞黏附和铺展，对于形态发生和发育过程中的正常细胞功能可能同样重要。已经描述了几种抗黏附蛋白，并且正在研究它们的作用机制。
