Albert Michael H, Notheis Gundula, Wintergerst Uwe, Born Christine, Schneider Karl
Department of Haematology/Oncology, Dr. von Haunersches Kinderspital, Lindwurmstrasse 4, 80337 Munich, Germany.
Pediatr Radiol. 2007 Feb;37(2):221-4. doi: 10.1007/s00247-006-0363-3. Epub 2006 Dec 21.
"Hair-on-end" skull changes are typically seen in individuals suffering from thalassaemia. They are induced by widening of the diploic space due to marrow expansion that is a consequence of ineffective and excessive erythropoiesis. We present a child with severe congenital neutropenia who exhibited the typical hair-on-end sign on plain skull radiographs and MRI. In this patient the skull changes were very likely induced by the expansion of white blood cell precursors induced by long-term daily injections of recombinant human granulocyte colony stimulating factor (G-CSF) to treat his confounding disease. This case report is the first description of hair-on-end changes associated with the use of G-CSF.
“头发直立”颅骨改变通常见于患有地中海贫血的个体。它们是由骨髓扩张导致的板障间隙增宽引起的，而骨髓扩张是无效和过度红细胞生成的结果。我们报告一名患有严重先天性中性粒细胞减少症的儿童，其在颅骨平片和磁共振成像（MRI）上表现出典型的“头发直立”征象。在该患者中，颅骨改变很可能是由于长期每日注射重组人粒细胞集落刺激因子（G-CSF）以治疗其复杂疾病所导致的白细胞前体扩张引起的。本病例报告是首次描述与使用G-CSF相关的“头发直立”改变。
