Y家族聚合酶的新功能。

New functions for Y family polymerases.

作者信息

Lehmann Alan R

机构信息

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom.

出版信息

Mol Cell. 2006 Nov 17;24(4):493-5. doi: 10.1016/j.molcel.2006.10.021.

DOI:10.1016/j.molcel.2006.10.021

PMID:17188030

Abstract

The Y family of DNA polymerases plays crucial roles in carrying out translesion synthesis past damaged bases in DNA. Several recent papers suggest that they might have other roles as well in gene conversion, in nucleotide excision repair (NER), and in DNA replication under stressed conditions.

摘要

DNA聚合酶Y家族在跨越DNA中受损碱基进行跨损伤合成过程中发挥着关键作用。最近的几篇论文表明，它们在基因转换、核苷酸切除修复（NER）以及应激条件下的DNA复制中可能也具有其他作用。