G蛋白偶联受体的结构与激活
G protein coupled receptor structure and activation.
作者信息
Kobilka Brian K
机构信息
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Biochim Biophys Acta. 2007 Apr;1768(4):794-807. doi: 10.1016/j.bbamem.2006.10.021. Epub 2006 Nov 15.
Abstract
G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.
摘要
G蛋白偶联受体（GPCRs）是极为多功能的信号分子。这个大家族的膜蛋白成员可被一系列结构多样的配体激活，并已证明能以配体特异性的方式调节不同信号通路的活性。在本论文中，我将主要围绕视紫红质和β2肾上腺素能受体这两个模型系统，综述关于GPCRs激活的结构和机制的已知信息。
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本文引用的文献
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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.将β2肾上腺素能受体中的配体结构与特定构象转换相耦合。
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Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.金属离子位点工程揭示了七跨膜受体激活的全局切换开关模型。
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Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor.使用原位二硫键交联策略研究M3毒蕈碱型乙酰胆碱受体跨膜结构域VI胞质端的动态特性。
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