Patti Francesco, Russo Pierluigi, Pappalardo Angelo, Macchia Francesco, Civalleri Liliana, Paolillo Andrea
Policlinico Universitario, Clinica Neurologica, Catania, Italy.
J Neurol Sci. 2007 Jan 31;252(2):121-9. doi: 10.1016/j.jns.2006.10.017. Epub 2006 Dec 22.
The Functional Assessment of Multiple Sclerosis (FAMS) quality of life (QoL) instrument is a disease-specific, self-report questionnaire that was developed originally for US English-speaking patients. Here, the psychometric properties of the FAMS QoL questionnaire for Italian-speaking patients with multiple sclerosis (MS) are evaluated and compared with the results from the original FAMS validation survey (n=377). Eighteen Italian centers and 344 patients with MS participated in the study. The overall reliability (as expressed by Cronbach's alpha value) of the FAMS score, and its subscale scores, was always over the threshold of 0.8. Patients with benign MS showed a better overall QoL compared with patients with relapsing-remitting MS (RRMS; p=0.017), whereas patients with RRMS had a better QoL than patients with primary progressive MS (PPMS). No difference in QoL was found between patients with PPMS and those with secondary progressive MS. The Italian FAMS questionnaire is a valid measure to assess the QoL concerns of patients with MS. FAMS is also easy to administer and is well accepted by patients.
多发性硬化症功能评估量表（FAMS）生活质量（QoL）工具是一种针对特定疾病的自填式问卷，最初是为美国说英语的患者开发的。在此，对意大利语多发性硬化症（MS）患者使用的FAMS生活质量问卷的心理测量特性进行评估，并与原始FAMS验证调查（n = 377）的结果进行比较。18个意大利中心和344例MS患者参与了该研究。FAMS评分及其子量表评分的总体信度（用Cronbach's α值表示）始终超过0.8的阈值。与复发缓解型MS（RRMS）患者相比，良性MS患者的总体生活质量更好（p = 0.017），而RRMS患者的生活质量优于原发性进展型MS（PPMS）患者。PPMS患者与继发性进展型MS患者之间的生活质量没有差异。意大利语FAMS问卷是评估MS患者生活质量问题的有效工具。FAMS也易于实施，并且患者接受度良好。
