YjjG是一种脱氧尿苷一磷酸磷酸酶，对大肠杆菌K-12利用胸腺嘧啶至关重要。
YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.
作者信息
Weiss Bernard
机构信息
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.
出版信息
J Bacteriol. 2007 Mar;189(5):2186-9. doi: 10.1128/JB.01645-06. Epub 2006 Dec 22.
Abstract
Exogenous thymine must be converted to thymidine to enable a thyA (thymidylate synthase) mutant to grow. The deoxyribose in the thymidine comes from dUMP, which must first be dephosphorylated. The nucleotidase YjjG is critical for this step. A yjjG thyA mutant cannot use thymine for growth on a glucose minimal medium.
摘要
外源性胸腺嘧啶必须转化为胸苷才能使thyA（胸苷酸合酶）突变体生长。胸苷中的脱氧核糖来自dUMP，dUMP必须首先被去磷酸化。核苷酸酶YjjG在这一步骤中至关重要。yjjG thyA突变体在葡萄糖基本培养基上不能利用胸腺嘧啶生长。
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