桑属植物中2-芳基苯并呋喃对耐甲氧西林金黄色葡萄球菌的抗菌活性。
Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus.
作者信息
Fukai Toshio, Kaitou Kiyoshi, Terada Sumio
机构信息
School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
出版信息
Fitoterapia. 2005 Dec;76(7-8):708-11. doi: 10.1016/j.fitote.2005.06.012. Epub 2005 Oct 19.
Nine 2-arylbenzofurans isolated from Morus species were tested for their antimicrobial activities against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Among these compounds, chalcomoracin (a leaf phytoalexine of mulberry tree) exhibited considerable antibacterial activity against MRSAs (MICs 0.78 mug/ml).
对从桑属植物中分离出的9种2-芳基苯并呋喃进行了测试，考察它们对甲氧西林敏感金黄色葡萄球菌（MSSA）、耐甲氧西林金黄色葡萄球菌（MRSA）、藤黄微球菌、枯草芽孢杆菌、大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌的抗菌活性。在这些化合物中，桑橙素（桑树叶片的一种植物抗毒素）对耐甲氧西林金黄色葡萄球菌表现出相当强的抗菌活性（最低抑菌浓度为0.78微克/毫升）。
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