来自小酸浆的抗利什曼原虫酸浆苦素

Antileishmanial physalins from Physalis minima.

作者信息

Choudhary M Iqbal, Yousaf Sammer, Ahmed Shakil, Yasmeen Kauser

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

Chem Biodivers. 2005 Sep;2(9):1164-73. doi: 10.1002/cbdv.200590086.

DOI:10.1002/cbdv.200590086

PMID:17193198

Abstract

Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses. Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.

摘要

从酸浆全草中分离出了三种新的酸浆苦素（1-3）和一种新的睡茄内酯7，以及三种已知的酸浆苦素：酸浆苦素H（4）、异酸浆苦素B（5）和5β,6β-环氧酸浆苦素B（6）。通过深入的光谱分析推断出了它们的结构。化合物1-6对硕大利什曼原虫前鞭毛体显示出显著的体外杀利什曼活性（0.92-19.4微克/毫升）。