Zhang Meng, Zhang Bingyang, Guang Chenxi, Jiang Benke, He Xinya, Cao Shijie, Ding Liqin, Kang Ning, Chen Lixia, Qiu Feng
School of Traditional Chinese Materia Medica, Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University Shenyang 110016 People's Republic of China
School of Chinese Materia Medica, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District Tianjin 301617 People's Republic of China.
RSC Adv. 2020 Jun 16;10(38):22819-22827. doi: 10.1039/d0ra04106h. eCollection 2020 Jun 10.
Seven previously undescribed withanolides, namely physaminilide A-G (1-7), and two artificial withanolides (8-9), along with 10 known analogues (10-19) were isolated from . The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. Cytotoxicity of all the isolates was evaluated against A375 human melanoma cells. Compounds 2, 5, 8, 10, 11 and 15 exhibited significant cytotoxic activities with IC values in the range of 1.2-9.4 μM.
从……中分离出7种先前未描述的睡茄内酯，即physaminilide A-G（1-7）和2种人工合成睡茄内酯（8-9），以及10种已知类似物（10-19）。通过光谱分析，包括核磁共振（NMR）和电子圆二色光谱（ECD）数据确定了其结构。评估了所有分离物对A375人黑素瘤细胞的细胞毒性。化合物2、5、8、10、11和15表现出显著的细胞毒性活性，IC值在1.2-9.4 μM范围内。
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