Meira Cássio Santana, Soares José Waldson Capinan, Dos Reis Bruna Padilha Zurita Claro, Pacheco Luciano Vasconcellos, Santos Ivanilson Pimenta, Silva Dahara Keyse Carvalho, de Lacerda Julia Costa, Daltro Sérgio Ricardo Teixeira, Guimarães Elisalva Teixeira, Soares Milena Botelho Pereira
SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador, Brazil.
Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Brazil.
Front Pharmacol. 2022 Apr 5;13:864714. doi: 10.3389/fphar.2022.864714. eCollection 2022.
Physalins, or 16,24-cyclo-13,14-seco steroids, are compounds belonging to the class of withanolides that can be found in plants of Solanaceae family, mainly in species belonging to the genus spp., which are annual herbaceous plants widely distributed in tropical and subtropical regions of the world. Physalins are versatile molecules that act in several cell signaling pathways and activate different mechanisms of cell death or immunomodulation. A number of studies have shown a variety of actions of these compounds, including anticancer, anti-inflammatory, antiparasitic, antimicrobial, antinociceptive, and antiviral activities. Here we reviewed the main findings related to the anticancer, immunomodulatory, and antiparasitic activities of physalins and its mechanisms of action, highlighting the \challenges and future directions in the pharmacological application of physalins.
酸浆苦素，即16,24-环-13,14-断甾体，是一类属于睡茄内酯的化合物，可在茄科植物中发现，主要存在于酸浆属植物中，这些植物是一年生草本植物，广泛分布于世界热带和亚热带地区。酸浆苦素是多功能分子，作用于多种细胞信号通路，激活不同的细胞死亡或免疫调节机制。许多研究表明了这些化合物的多种作用，包括抗癌、抗炎、抗寄生虫、抗菌、抗伤害感受和抗病毒活性。在此，我们综述了与酸浆苦素的抗癌、免疫调节和抗寄生虫活性及其作用机制相关的主要研究结果，突出了酸浆苦素在药理学应用中的挑战和未来方向。
