来自小酸浆的新型杀利什曼原虫酸浆苦素
New leishmanicidal physalins from Physalis minima.
作者信息
Choudhary M Iqbal, Yousuf Sammer, Ahmed Shakil
机构信息
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
出版信息
Nat Prod Res. 2007 Aug;21(10):877-83. doi: 10.1080/14786410701315147.
Two new physalins, 16,24-cyclo-13,14-secoergosta-2-ene-18,26-dioic acid-14 : 17,14 : 27-diepoxy-11beta,13,20,22-tetrahydroxy-5alpha-methoxy-1,15-dioxo-gamma-lactone delta-lactone (1), and 16,24-cyclo-13,14-secoergosta-2-ene-18,26-dioic acid-14 : 17,14 : 27-diepoxy-5alpha,11beta,13,20,22-pentahydroxy-1,6,15-trioxo-gamma-lactone delta-lactone (2), have been isolated from the whole plant of Physalis minima Linn. (var. indica). Their structures were deduced on the basis of spectroscopic analysis. Both of these compounds have shown potent leishmanicidal activity against the promastigotes of Leishmania major.
从酸浆（印度变种）全株中分离出了两种新的酸浆苦素，即16,24-环-13,14-开环麦角甾-2-烯-18,26-二酸-14:17,14:27-二环氧-11β,13,20,22-四羟基-5α-甲氧基-1,15-二氧代-γ-内酯δ-内酯（1）和16,24-环-13,14-开环麦角甾-2-烯-18,26-二酸-14:17,14:27-二环氧-5α,11β,13,20,22-五羟基-1,6,15-三氧代-γ-内酯δ-内酯（2）。它们的结构是通过光谱分析推导出来的。这两种化合物对硕大利什曼原虫的前鞭毛体均显示出强大的杀利什曼活性。
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