Ito Tetsuro, Ali Zulfiqar, Furusawa Miyuki, Iliya Ibrahim, Tanaka Toshiyuki, Nakaya Ken-ichi, Murata Jin, Darnaedi Dedy, Oyama Masayoshi, Iinuma Munekazu
Gifu Prefectural Institute of Health and Environmental Sciences, 1-1 Naka-fudogaoka, Kakamigahara 504-0838, Japan.
Chem Biodivers. 2005 Sep;2(9):1200-16. doi: 10.1002/cbdv.200590091.
Two new resveratrol (= 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) trimers, cotylelophenols A (1) and B (2), were isolated from the stem of Cotylelobium lanceolatum (Dipterocarpaceae), together with ten known resveratrol oligomers (3-12). The structures of the isolates were established on the basis of spectroscopic analyses, including a detailed NMR spectroscopic investigation of 1 under different conditions. Compound 1 is the first resveratrol trimer with a rearranged 4-hydroxyphenyl group. Four possible biogenetic pathways towards resveratrol oligomers are proposed (Scheme).
从披针叶柯（龙脑香科）的茎中分离出两种新的白藜芦醇（= 5-[(E)-2-(4-羟基苯基)乙烯基]苯-1,3-二醇）三聚体，柯叶酚A（1）和B（2），以及十种已知的白藜芦醇低聚物（3 - 12）。通过光谱分析确定了分离物的结构，包括在不同条件下对1进行详细的核磁共振光谱研究。化合物1是首个具有重排4-羟基苯基的白藜芦醇三聚体。提出了白藜芦醇低聚物的四种可能生物合成途径（方案）。
