龙脑香科植物白藜芦醇衍生物对酪氨酸酶活性的抑制作用。
Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity.
作者信息
Ohguchi Kenji, Tanaka Toshiyuki, Ito Tetsuro, Iinuma Munekazu, Matsumoto Kenji, Akao Yukihiro, Nozawa Yoshinori
机构信息
Gifu International Institute of Biotechnology, Kakamigahara, Japan.
出版信息
Biosci Biotechnol Biochem. 2003 Jul;67(7):1587-9. doi: 10.1271/bbb.67.1587.
Stilbene derivatives, which are resveratrol (3,4',5-trihydroxy-trans-stilbene) oligomers ranging from monomer to tetramer, isolated from Dipterocarpaceae plants were tested for their inhibitory effects against murine tyrosinase activity. The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency.
从龙脑香科植物中分离得到的二苯乙烯衍生物，即白藜芦醇（3,4',5-三羟基反式二苯乙烯）从单体到四聚体的低聚物，被测试了它们对小鼠酪氨酸酶活性的抑制作用。本研究中获得的构效关系表明，二苯乙烯骨架中的双键对抑制作用至关重要，并且分子大小对抑制效力也很重要。
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