Larson Bruce A, Amin Abdinasir A, Noor Abdisalan M, Zurovac Dejan, Snow Robert W
Center for International Health and Development, Boston University, 85 East Concord Street, 5th Floor, Boston, MA 02118, USA.
BMC Public Health. 2006 Dec 29;6:314. doi: 10.1186/1471-2458-6-314.
Fever is the clinical hallmark of malaria disease. The Roll Back Malaria (RBM) movement promotes prompt, effective treatment of childhood fevers as a key component to achieving its optimistic mortality reduction goals by 2010. A neglected concern is how communities will access these new medicines promptly and the costs to poor households when they are located in rural areas distant to health services.
We assemble data developed between 2001 and 2002 in Kenya to describe treatment choices made by rural households to treat a child's fever and the related costs to households. Using a cost-of-illness approach, we estimate the expected cost of a childhood fever to Kenyan households in 2002. We develop two scenarios to explore how expected costs to households would change if more children were treated at a health care facility with an effective antimalarial within 48 hours of fever onset.
30% of uncomplicated fevers were managed at home with modern medicines, 38% were taken to a health care facility (HCF), and 32% were managed at home without the use of modern medicines. Direct household cash expenditures were estimated at $0.44 per fever, while the total expected cost to households (cash and time) of an uncomplicated childhood fever is estimated to be $1.91. An estimated mean of 1.42 days of caretaker time devoted to each fever accounts for the majority of household costs of managing fevers. The aggregate cost to Kenyan households of managing uncomplicated childhood fevers was at least $96 million in 2002, equivalent to 1.00% of the Kenyan GDP. Fewer than 8% of all fevers were treated with an antimalarial drug within 24 hours of fever onset, while 17.5% were treated within 48 hours at a HCF. To achieve an increase from 17.5% to 33% of fevers treated with an antimalarial drug within 48 hours at a HCF (Scenario 1), children already being taken to a HCF would need to be taken earlier. Under this scenario, direct cash expenditures would not change, and total household costs would fall slightly to $1.86 because caretakers also save time with prompt treatment if the child has malaria.
The management of uncomplicated childhood fevers imposes substantial costs on Kenyan households. Achieving substantial improvements in the numbers of fevers treated within 48 hours at a HCF with an effective antimalarial drug (Scenario 1) will not impose additional costs on households. Achieving additional improvements in fevers treated promptly at a HCF (Scenario 2) will impose additional costs on some households roughly equal to average cash expenses for transportation to a HCF. Additional financing mechanisms that further reduce the costs of accessing care at a HCF and/or that make artemisinin-based combination therapies (ACTs) accessible for home management need to be developed and evaluated as a top priority.
发热是疟疾疾病的临床标志。遏制疟疾伙伴关系(RBM)运动将促进对儿童发热进行及时、有效的治疗作为实现其到2010年降低死亡率这一乐观目标的关键组成部分。一个被忽视的问题是,当社区位于远离卫生服务机构的农村地区时,他们将如何及时获得这些新药以及贫困家庭为此要付出的成本。
我们汇总了2001年至2002年期间在肯尼亚收集的数据,以描述农村家庭治疗儿童发热所做的治疗选择以及家庭为此付出的相关成本。我们采用疾病成本法,估算了2002年肯尼亚家庭儿童发热的预期成本。我们制定了两种情景,以探讨如果更多儿童在发热开始后48小时内于医疗机构接受有效的抗疟治疗,家庭的预期成本会如何变化。
30%的非复杂性发热在家中使用现代药物治疗,38%被带到医疗机构(HCF),32%在家中未使用现代药物治疗。每次发热家庭直接现金支出估计为0.44美元,而非复杂性儿童发热家庭的总预期成本(现金和时间)估计为1.91美元。估计每次发热看护人平均投入1.42天时间,这占家庭治疗发热成本的大部分。2002年肯尼亚家庭治疗非复杂性儿童发热的总成本至少为9600万美元,相当于肯尼亚国内生产总值的1.00%。在发热开始后24小时内,使用抗疟药物治疗的发热病例不到8%,而在医疗机构48小时内接受治疗的占17.5%。为了使在医疗机构48小时内使用抗疟药物治疗的发热病例比例从17.5%提高到33%(情景1),已经被带到医疗机构的儿童需要更早就诊。在这种情景下,直接现金支出不会改变,家庭总成本将略有下降至1.86美元,因为如果孩子患疟疾,及时治疗也会使看护人节省时间。
非复杂性儿童发热的治疗给肯尼亚家庭带来了巨大成本。在医疗机构48小时内使用有效的抗疟药物治疗更多发热病例(情景1)不会给家庭带来额外成本。在医疗机构进一步提高及时治疗发热病例的比例(情景2)将给一些家庭带来额外成本,大致相当于前往医疗机构的平均交通现金费用。需要作为首要任务制定并评估进一步降低在医疗机构就诊成本和/或使青蒿素类复方疗法(ACTs)可用于家庭治疗的额外筹资机制。