Traul David E, Shaffrey Mark E, Schiff David
Department of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Lancet Oncol. 2007 Jan;8(1):35-45. doi: 10.1016/S1470-2045(06)71009-9.
Intradural spinal-cord tumours are an uncommon but important consideration in the differential diagnosis of patients with back pain, radicular pain, sensorimotor deficits, or sphincter dysfunction. Intradural spinal tumours can be divided into intramedullary and extramedullary spinal-cord tumours on the basis of their anatomical relation to the spinal parenchyma. The heterogeneous cell composition of the intradural compartment allows the formation of neoplasms, arising from glial cells, neurons, and cells of spinal vasculature. Additionally, developmental tumours, metastases, and intradural extension of extradural tumours are represented. In this Review, we discuss the published work on intradural spinal-cord tumours in terms of epidemiological, radiographic, and histological characteristics. Surgical and adjuvant treatment strategies are also reviewed.
硬脊膜内脊髓肿瘤在背痛、神经根性疼痛、感觉运动功能障碍或括约肌功能障碍患者的鉴别诊断中虽不常见但很重要。根据硬脊膜内脊髓肿瘤与脊髓实质的解剖关系，可分为髓内和髓外脊髓肿瘤。硬脊膜内腔的细胞组成异质性使得由神经胶质细胞、神经元和脊髓脉管系统细胞形成肿瘤成为可能。此外，还包括发育性肿瘤、转移瘤以及硬膜外肿瘤的硬脊膜内扩展。在本综述中，我们根据流行病学、影像学和组织学特征，讨论已发表的关于硬脊膜内脊髓肿瘤的研究成果。同时也对手术及辅助治疗策略进行了综述。
