Dubé Celine
Department of Anatomy & Neurobiology, ZOT 1275, University of California Irvine, Irvine, CA 92697, United States.
Peptides. 2007 Feb;28(2):441-6. doi: 10.1016/j.peptides.2006.08.034. Epub 2006 Dec 29.
Seizures induce profound plastic changes in the brain, including altered expression of neuropeptide Y (NPY) and its receptors. Here, I discuss a potential role of NPY plasticity in the developmental brain: in a rat model of febrile seizures (FS), the most common type of seizures in infants and young children, NPY expression was up-regulated in hippocampus after experimentally induced FS. Interestingly, NPY up-regulation was associated with an increased seizure threshold for additional (recurrent) FS, and this effect was abolished when an antagonist against NPY receptor type 2 was applied. These findings suggest that inhibitory actions of NPY, released after seizures, exert a protective effect that reduces the risk of seizure recurrence in the developing brain.
癫痫发作会在大脑中引发深刻的可塑性变化，包括神经肽Y（NPY）及其受体表达的改变。在此，我讨论NPY可塑性在发育中大脑的潜在作用：在热性惊厥（FS）的大鼠模型中，FS是婴幼儿最常见的癫痫发作类型，实验性诱导FS后，海马体中的NPY表达上调。有趣的是，NPY上调与额外（复发性）FS的癫痫发作阈值增加有关，当应用针对2型NPY受体的拮抗剂时，这种效应被消除。这些发现表明，癫痫发作后释放的NPY的抑制作用发挥了保护作用，降低了发育中大脑癫痫复发的风险。
