Santos Victor R, Tilelli Cristiane Q, Fernandes Artur, de Castro Olagide Wagner, Del-Vecchio Flávio, Garcia-Cairasco Norberto
Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, MG, Brazil.
IBRO Neurosci Rep. 2023 Jun 7;15:68-76. doi: 10.1016/j.ibneur.2023.06.001. eCollection 2023 Dec.
About 1-2% of people worldwide suffer from epilepsy, which is characterized by unpredictable and intermittent seizure occurrence. Despite the fact that the exact origin of temporal lobe epilepsy is frequently unknown, it is frequently linked to an early triggering insult like brain damage, tumors, or (SE). We used an experimental approach consisting of electrical stimulation of the amygdaloid complex to induce two behaviorally and structurally distinct SE states: Type I (fully convulsive), with more severe seizure behaviors and more extensive brain damage, and Type II (partial convulsive), with less severe seizure behaviors and brain damage. Our goal was to better understand how the various types of SE impact the hippocampus leading to the development of epilepsy. Despite clear variations between the two behaviors in terms of neurodegeneration, study of neurogenesis revealed a comparable rise in the number of Ki-67 + cells and an increase in Doublecortin (DCX) in both kinds of SE.
全球约1%-2%的人患有癫痫，其特征是癫痫发作不可预测且间歇性发生。尽管颞叶癫痫的确切起源常常不明，但它通常与早期触发损伤有关，如脑损伤、肿瘤或癫痫持续状态（SE）。我们采用了一种实验方法，通过对杏仁核复合体进行电刺激来诱导两种行为和结构上不同的癫痫持续状态：I型（完全惊厥性），具有更严重的癫痫发作行为和更广泛的脑损伤；II型（部分惊厥性），具有较轻的癫痫发作行为和脑损伤。我们的目标是更好地了解不同类型的癫痫持续状态如何影响海马体从而导致癫痫的发展。尽管在神经退行性变方面这两种行为存在明显差异，但神经发生研究显示，两种类型的癫痫持续状态中Ki-67 +细胞数量均有类似增加，双皮质素（DCX）也有所增加。
