Brookes Matthew J, Stevenson Claire M, Barnes Gareth R, Hillebrand Arjan, Simpson Michael I G, Francis Susan T, Morris Peter G
The Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Neuroimage. 2007 Feb 15;34(4):1454-65. doi: 10.1016/j.neuroimage.2006.11.012. Epub 2006 Dec 29.
This paper introduces a lead field formulation for use in beamformer analysis of MEG data. This 'dual source beamformer' is a technique to image two temporally correlated sources using beamformer methodology. We show that while the standard, single source beamformer suppresses the reconstructed power of two spatially separate but temporally correlated sources, the dual source beamformer allows for their accurate reconstruction. The technique is proven to be accurate using simulations. We also show that it can be used to image accurately the auditory steady state response, which is correlated between the left and right auditory cortices. We suggest that this technique represents a useful way of locating correlated sources, particularly if a seed location can be defined a priori for one of the two sources. Such a priori information could be based on previous studies using similar paradigms, or from other functional neuroimaging techniques.
本文介绍了一种用于脑磁图(MEG)数据波束形成器分析的导联场公式。这种“双源波束形成器”是一种使用波束形成方法对两个时间相关源进行成像的技术。我们表明,虽然标准的单源波束形成器会抑制两个空间分离但时间相关源的重建功率,但双源波束形成器能够对其进行准确重建。通过模拟证明了该技术的准确性。我们还表明,它可用于准确成像听觉稳态反应,该反应在左右听觉皮层之间具有相关性。我们认为,这种技术是定位相关源的一种有用方法,特别是如果可以为两个源之一先验定义一个种子位置。这样的先验信息可以基于以前使用类似范式的研究,或来自其他功能神经成像技术。