Center for Music in the Brain (MIB), Department of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg, Universitetsbyen 3, 8000, Aarhus C, Denmark.
Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Stoke place 7, OX39BX, Oxford, UK.
Cereb Cortex. 2023 Apr 25;33(9):5524-5537. doi: 10.1093/cercor/bhac439.
Memory for sequences is a central topic in neuroscience, and decades of studies have investigated the neural mechanisms underlying the coding of a wide array of sequences extended over time. Yet, little is known on the brain mechanisms underlying the recognition of previously memorized versus novel temporal sequences. Moreover, the differential brain processing of single items in an auditory temporal sequence compared to the whole superordinate sequence is not fully understood. In this magnetoencephalography (MEG) study, the items of the temporal sequence were independently linked to local and rapid (2-8 Hz) brain processing, while the whole sequence was associated with concurrent global and slower (0.1-1 Hz) processing involving a widespread network of sequentially active brain regions. Notably, the recognition of previously memorized temporal sequences was associated to stronger activity in the slow brain processing, while the novel sequences required a greater involvement of the faster brain processing. Overall, the results expand on well-known information flow from lower- to higher order brain regions. In fact, they reveal the differential involvement of slow and faster whole brain processing to recognize previously learned versus novel temporal information.
记忆序列是神经科学的一个核心主题，数十年来的研究已经调查了在时间上扩展的各种序列的编码所涉及的神经机制。然而，对于先前记忆的与新的时间序列之间的识别的大脑机制知之甚少。此外，与整个上级序列相比，听觉时间序列中单一项的大脑处理的差异尚未完全理解。在这项脑磁图（MEG）研究中，时间序列的项目分别与局部和快速（2-8 Hz）脑处理相关联，而整个序列则与同时发生的全局和较慢（0.1-1 Hz）处理相关联，涉及到顺序活跃的脑区的广泛网络。值得注意的是，先前记忆的时间序列的识别与较慢的脑处理中的更强的活动相关联，而新的序列则需要更快的脑处理的更大参与。总体而言，这些结果扩展了从低等脑区到高等脑区的已知信息流。实际上，它们揭示了慢和快的整个大脑处理的差异参与来识别先前学习的与新的时间信息。
