Ueno T, Inuzuka S, Torimura T, Sakata R, Sakamoto M, Gondo K, Aoki T, Tanikawa K, Tsutsumi V
Second Department of Medicine, Kurume University School of Medicine, Japan.
Am J Gastroenterol. 1991 Nov;86(11):1633-7.
The localization of substance P (SP) and vasoactive intestinal peptide (VIP) in 12 normal human liver tissues was examined by light and electron immunohistochemistry using immunoperoxidase methods. SP and VIP immunoreactive nerve fibers were observed around portal veins, bile ducts, and hepatic arteries in portal areas, along sinusoids and hepatocytes in hepatic lobules, and around central veins. More SP and VIP immunoreactive nerve fibers were present in the portal areas than in other regions. Moreover, SP and VIP containing nerve endings were localized close to myofibroblasts, Ito cells, fibroblasts and endothelial cells of blood vessels, and sinusoids. The results suggested that part of the innervation of the human liver may be related to the contraction and relaxation of the cells close to nerve endings, and to the regulation of hemodynamic processes by the neurotransmitters such as SP and VIP at the hepatic lobular level.
采用免疫过氧化物酶法，通过光镜和电镜免疫组织化学技术检测了12例正常人体肝组织中P物质（SP）和血管活性肠肽（VIP）的定位。在门管区的门静脉、胆管和肝动脉周围，肝小叶内的肝血窦和肝细胞周围以及中央静脉周围均观察到SP和VIP免疫反应性神经纤维。门管区的SP和VIP免疫反应性神经纤维比其他区域更多。此外，含有SP和VIP的神经末梢定位于肌成纤维细胞、贮脂细胞、成纤维细胞以及血管和肝血窦的内皮细胞附近。结果表明，人类肝脏的部分神经支配可能与神经末梢附近细胞的收缩和舒张有关，并且与肝小叶水平上诸如SP和VIP等神经递质对血流动力学过程的调节有关。
