Deslandes Andréa, Ferreira Camila, Veiga Heloisa, Cagy Maurício, Piedade Roberto, Pompeu Fernando, Ribeiro Pedro
Setor de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 22793-395, Brazil.
Neuropsychobiology. 2006;54(2):126-33. doi: 10.1159/000098263. Epub 2007 Jan 3.
Caffeine is regarded as a central nervous system (CNS) stimulant. The goal of this study was to analyze electrophysiological, motor, cognitive and behavioral changes produced by caffeine ingestion after sleep deprivation. Ten subjects were evaluated after sleep deprivation, comparing the ingestion of either 400 mg of caffeine or placebo, in a double-blind randomized study. The variables analyzed were: quantitative EEG, the event-related potential (ERP-P300) and cognitive responses. The most significant quantitative EEG results, which were characterized by moment x treatment interactions, were seen in alpha and theta relative power variables. A significant decrease in relative alpha and theta was observed in the caffeine group after sleep deprivation. In relation to caffeine stimulant effects, there were no significant differences in the other parameters.
咖啡因被视为一种中枢神经系统（CNS）兴奋剂。本研究的目的是分析睡眠剥夺后摄入咖啡因所产生的电生理、运动、认知和行为变化。在一项双盲随机研究中，对10名受试者在睡眠剥夺后进行了评估，比较了摄入400毫克咖啡因或安慰剂的情况。分析的变量包括：定量脑电图、事件相关电位（ERP-P300）和认知反应。在α和θ相对功率变量中观察到最显著的定量脑电图结果，其特征为时刻x治疗交互作用。睡眠剥夺后，咖啡因组的相对α和θ显著降低。关于咖啡因的刺激作用，其他参数没有显著差异。
