Irisawa Satoshi, Isotani Toshiaki, Yagyu Takami, Morita Sachi, Nishida Keiichiro, Yamada Keizo, Yoshimura Masafumi, Okugawa Gaku, Nobuhara Kenji, Kinoshita Toshihiko
Department of Neuropsychiatry, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan.
Neuropsychobiology. 2006;54(2):134-9. doi: 10.1159/000098264. Epub 2007 Jan 3.
To explore brain functions in schizophrenic patients, the global analytic strategy of multichannel EEG was performed that combines measures of global complexity (Omega), total power (Sigma) and generalized frequency (Phi), and EEG microstate analysis was applied to multichannel EEG data for 24 nonmedicated patients and 24 healthy subjects. The patients had higher Omega and Sigma values, and lower Phi values compared with healthy subjects. Three topographical classes were obtained from all EEG data by EEG microstate analysis. The mean duration of one topographical class in the patients was shortened compared to healthy subjects. These results indicated looser cooperativity, or decreased connectivity of the active brain process and deviant brain information processing in schizophrenic patients.
为探究精神分裂症患者的脑功能，采用了多通道脑电图的整体分析策略，该策略结合了整体复杂性（欧米伽）、总功率（西格玛）和广义频率（披）的测量方法，并将脑电图微状态分析应用于24名未服药患者和24名健康受试者的多通道脑电图数据。与健康受试者相比，患者的欧米伽和西格玛值较高，披值较低。通过脑电图微状态分析从所有脑电图数据中获得了三个地形类别。与健康受试者相比，患者中一个地形类别的平均持续时间缩短。这些结果表明，精神分裂症患者的协同性较松散，或活跃脑过程的连接性降低以及脑信息处理异常。
