Rasouli Neda, Molavi Behzad, Elbein Steven C, Kern Philip A
The Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.
Diabetes Obes Metab. 2007 Jan;9(1):1-10. doi: 10.1111/j.1463-1326.2006.00590.x.
The recent escalation of obesity from an individual health problem to a major public health issue reaching epidemic proportions has drawn attention to a constellation of abnormalities (abdominal obesity, hypertension and dyslipidaemia) collectively referred to as metabolic syndrome. As an indicator of insulin resistance and a harbinger of diabetes, this syndrome has been associated with major cardiovascular mortality and morbidity. Yet, the exact pathophysiological events leading to the development of metabolic syndrome remain unknown. We review some of the current literature on the pathogenesis of metabolic syndrome with an emphasis on the role of ectopic lipid accumulation.
近期，肥胖问题已从个人健康问题升级为一个达到流行程度的重大公共卫生问题，这引发了人们对一系列异常情况（腹部肥胖、高血压和血脂异常）的关注，这些异常情况统称为代谢综合征。作为胰岛素抵抗的指标和糖尿病的先兆，该综合征与主要的心血管死亡率和发病率相关。然而，导致代谢综合征发生的确切病理生理事件仍不清楚。我们回顾了一些关于代谢综合征发病机制的当前文献，重点关注异位脂质蓄积的作用。
