9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯治疗仓鼠马流产病毒诱导性肝炎的疗效
Efficacy of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters.
作者信息
Allen L B, Huffman J H, Revankar G R, Tolman R L, Simon L N, Robins R K, Sidwell R W
出版信息
Antimicrob Agents Chemother. 1975 Oct;8(4):474-8. doi: 10.1128/AAC.8.4.474.
Abstract
Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of approximately 60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.
摘要
马流产病毒（EAV）诱发的仓鼠肝炎为评估具有抗脱氧核糖核酸病毒活性的药物提供了一个有趣的动物模型。这些实验表明，新型合成水溶性抗病毒药物9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯（ara-HxMP）能有效控制仓鼠的这种疾病，其治疗指数约为60。ara-HxMP可预防仓鼠因肝炎导致的死亡，降低仓鼠体内EAV的滴度，并抑制EAV感染仓鼠血清谷丙转氨酶的升高。
相似文献
1
Efficacy of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters.9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯治疗仓鼠马流产病毒诱导性肝炎的疗效
Antimicrob Agents Chemother. 1975 Oct;8(4):474-8. doi: 10.1128/AAC.8.4.474.
2
Inhibition of experimental deoxyribonucleic acid virus-induced encephalitis by 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate.5'-单磷酸9-β-D-阿拉伯呋喃糖基次黄嘌呤对实验性脱氧核糖核酸病毒诱导的脑炎的抑制作用
Antimicrob Agents Chemother. 1975 Oct;8(4):468-73. doi: 10.1128/AAC.8.4.468.
3
Effect of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate on experimental herpes simplex keratitis.9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸酯和9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯对实验性单纯疱疹性角膜炎的作用
Antimicrob Agents Chemother. 1976 Dec;10(6):885-8. doi: 10.1128/AAC.10.6.885.
4
Viral keratitis-inhibitory effect of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate.9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯对病毒性角膜炎的抑制作用
Antimicrob Agents Chemother. 1975 Oct;8(4):463-7. doi: 10.1128/AAC.8.4.463.
5
Effect of antiviral agents in equine abortion virus-infected hamsters.抗病毒药物对感染马流产病毒的仓鼠的影响。
Antimicrob Agents Chemother. 1972 Feb;1(2):143-7. doi: 10.1128/AAC.1.2.143.
6
Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.阿糖胸腺嘧啶在疱疹病毒复制中的抗病毒活性：体内和体外作用机制
Antimicrob Agents Chemother. 1977 Aug;12(2):243-54. doi: 10.1128/AAC.12.2.243.
7
Virus-induced abortion. Studies of equine herpesvirus 1 (abortion virus) in hamsters.病毒诱导的流产。仓鼠中马疱疹病毒1型（流产病毒）的研究。
Lab Invest. 1975 Oct;33(4):400-6.
8
Composition of RNA and DNA of citric acid-isolated liver nuclei from hamsters infected with equine abortion virus (EAV).感染马流产病毒（EAV）的仓鼠经柠檬酸分离的肝细胞核中RNA和DNA的组成
Virology. 1960 Aug;11:773-5. doi: 10.1016/0042-6822(60)90121-5.
9
Synthesis and antiviral activity of certain 5'-monophosphates of 9-D-arabinofuranosyladenine and 9-D-arabinofuranosylhypoxanthine.
J Med Chem. 1975 Jul;18(7):721-6. doi: 10.1021/jm00241a016.
10
Protective immunity in equine herpesvirus type I infection of hamsters.
Cornell Vet. 1977 Jul;67(3):385-403.
引用本文的文献
1
Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1.用马疱疹病毒1诱导流产的小鼠模型研究膦酰甲氧基烷基衍生物的作用。
Antimicrob Agents Chemother. 1993 Nov;37(11):2478-82. doi: 10.1128/AAC.37.11.2478.
2
Relative activities of acyclovir and BW759 against Aujeszky's disease and equine rhinopneumonitis viruses.阿昔洛韦和BW759对伪狂犬病病毒和马鼻肺炎病毒的相对活性。
Antimicrob Agents Chemother. 1983 Aug;24(2):221-6. doi: 10.1128/AAC.24.2.221.
3
Susceptibility of bovid herpesvirus 1 to antiviral drugs: in vitro versus in vivo efficacy of (E)-5-(2-Bromovinyl)-2'-deoxyuridine.牛疱疹病毒1对抗病毒药物的敏感性：（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的体外与体内疗效
Antimicrob Agents Chemother. 1983 May;23(5):715-20. doi: 10.1128/AAC.23.5.715.
4
Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease.腺嘌呤的膦酰基甲氧基烷基衍生物对马疱疹病毒1的有效化疗在该疾病的新型小鼠模型中得到证实。
Antimicrob Agents Chemother. 1990 May;34(5):709-17. doi: 10.1128/AAC.34.5.709.
5
Viral keratitis-inhibitory effect of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate.9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯对病毒性角膜炎的抑制作用
Antimicrob Agents Chemother. 1975 Oct;8(4):463-7. doi: 10.1128/AAC.8.4.463.
6
Effect of ribavirin on viral hepatitis in laboratory animals.利巴韦林对实验动物病毒性肝炎的影响。
Ann N Y Acad Sci. 1977 Mar 4;284(1):239-46. doi: 10.1111/j.1749-6632.1977.tb21956.x.
本文引用的文献
1
2
Propagation of equine abortion virus in Syrian hamsters.马流产病毒在叙利亚仓鼠中的传播。
Cornell Vet. 1956 Jan;46(1):68-82.
3
DNA of a human hepatitis B virus candidate.一种人类乙型肝炎病毒候选物的DNA。
J Virol. 1974 Aug;14(2):384-91. doi: 10.1128/JVI.14.2.384-391.1974.
4
Recent developments in viral hepatitis therapy.病毒性肝炎治疗的最新进展。
Geriatrics. 1973 Apr;28(4):100-3.
5
Effect of antiviral agents in equine abortion virus-infected hamsters.抗病毒药物对感染马流产病毒的仓鼠的影响。
Antimicrob Agents Chemother. 1972 Feb;1(2):143-7. doi: 10.1128/AAC.1.2.143.
6
Synthesis and antiviral activity of certain 5'-monophosphates of 9-D-arabinofuranosyladenine and 9-D-arabinofuranosylhypoxanthine.
J Med Chem. 1975 Jul;18(7):721-6. doi: 10.1021/jm00241a016.
Zotero 插件