Sidwell R W, Allen L B, Huffman J H, Revankar G R, Robins R K, Tolman R L
Antimicrob Agents Chemother. 1975 Oct;8(4):463-7. doi: 10.1128/AAC.8.4.463.
Topical application of 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP) significantly inhibited the development of keratitis induced by types 1 and 2 herpes simplex virus and vaccinia virus in the eyes of rabbits. Parameters for evaluation of efficacy were infectivity (corneal opacity, lesion size, and type), Draize (erythema, conjunctival swelling, and discharge), and reduction in titer of recoverable virus from the eye. When the relative efficacy of the related compounds 9-beta-d-arabinofuranosyladenine (ara-A), ara-A 5'-monophosphate (ara-AMP), and ara-Hx was determined against type 1 herpes simplex virus in a parallel experiment, the more water-soluble compounds (ara-HxMP, ara-AMP) were the most effective. The relative efficacy of ara-A was also determined against type 2 herpes and vaccinia virus-induced keratitis. Mortality in rabbits due to central nervous system involvement caused by types 1 and 2 herpes simplex virus was inhibited. Ara-HxMP was not discernibly toxic to the eye at concentrations of at least 20%; efficacy was still discernible with a 0.1% solution.
9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯（ara-HxMP）的局部应用显著抑制了1型和2型单纯疱疹病毒以及痘苗病毒诱导的家兔角膜炎的发展。评估疗效的参数包括感染性（角膜混浊、病变大小和类型）、德雷兹（红斑、结膜肿胀和分泌物）以及眼内可回收病毒滴度的降低。在一项平行实验中，当测定相关化合物9-β-D-阿拉伯呋喃糖基腺嘌呤（ara-A）、ara-A 5'-单磷酸酯（ara-AMP）和ara-Hx对1型单纯疱疹病毒的相对疗效时，水溶性更高的化合物（ara-HxMP、ara-AMP）最为有效。还测定了ara-A对2型单纯疱疹和痘苗病毒诱导的角膜炎的相对疗效。1型和2型单纯疱疹病毒引起的中枢神经系统受累导致的家兔死亡率受到抑制。在至少20%的浓度下，ara-HxMP对眼睛没有明显毒性；0.1%的溶液仍可观察到疗效。
