Johal A, Hector M P, Battagel J M, Kotecha B T
Oral Growth and Development, Institute of Dentistry, Barts & The London Queen Mary's School of Medicine and Dentistry, London, UK.
J Laryngol Otol. 2007 Jul;121(7):668-75. doi: 10.1017/S0022215106003203. Epub 2007 Jan 4.
To evaluate the impact of positive sleep nasendoscopy, with simultaneous mandibular advancement, on the outcome of mandibular advancement splint therapy in 120 subjects with sleep-related breathing disorders.
Overnight polysomnography and sleep nasendoscopy were performed prior to splint therapy. Follow-up sleep studies, with the appliance in situ, were undertaken for those patients with obstructive sleep apnoea. Subjective outcome measures assessed daytime sleepiness and snoring.
One hundred and seven (89 per cent) subjects completed the study. Follow-up sleep studies confirmed the efficacy of treatment, with patients showing a mean reduction in apnoea/hypopnoea index (from 18.9 to 4.9, p<0.001), Epworth sleepiness scale scores (from 11 to seven, p<0.001) and partner-recorded snoring scores (from 14 to eight, p<0.001).
Sleep nasendoscopy, with concomitant mandibular advancement to mimic the treatment effect, could be of prognostic value in determining successful mandibular advancement splint therapy.
评估在120例睡眠相关呼吸障碍患者中，积极睡眠鼻内镜检查联合下颌前伸对下颌前伸矫治器治疗效果的影响。
在矫治器治疗前进行整夜多导睡眠图和睡眠鼻内镜检查。对阻塞性睡眠呼吸暂停患者在佩戴矫治器的情况下进行随访睡眠研究。主观结果指标评估日间嗜睡和打鼾情况。
107例（89%）受试者完成了研究。随访睡眠研究证实了治疗的有效性，患者的呼吸暂停/低通气指数平均降低（从18.9降至4.9，p<0.001），爱泼沃斯嗜睡量表评分（从11降至7，p<0.001），以及伴侣记录的打鼾评分（从14降至8，p<0.001）。
睡眠鼻内镜检查联合下颌前伸以模拟治疗效果，在确定下颌前伸矫治器治疗成功方面可能具有预后价值。
