Vogelbaum Michael A
Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA.
J Neurooncol. 2007 May;83(1):97-109. doi: 10.1007/s11060-006-9308-9. Epub 2007 Jan 4.
In 2003 the Cleveland Clinic Brain Tumor Institute sponsored a symposium to mark the progress being made in what was then a new approach to treating brain tumors - convection enhanced delivery (CED) [Vogelbaum MA (2005) J NeuroOncol 73(1):57-69]. A second symposium was held in February, 2006, to review new accomplishments and identify promising avenues of research in this evolving but still novel therapy. Among the general subjects covered by a host of international experts in their respective fields were advances in CED technology, new clinical applications of the technology, advances in CED-related imaging procedures, reviews of current or proposed trials, new drugs and the status of projects moving from lab to clinical practice. Specific subjects included the design of new catheters, the development of mathematic models for planning, novel therapeutics for CED treatment of stroke, spinal cord degenerative disease and epilepsy, liposome-based agents administered via CED, ultra-sound driven CED, monitoring the in vivo effects of intratumoral paclitaxel and other topics. Each speaker's presentation has been abstracted along with relevant references.
2003年，克利夫兰诊所脑瘤研究所主办了一次研讨会，以纪念当时一种治疗脑瘤的新方法——对流增强递送（CED）所取得的进展[沃格尔鲍姆·马A（2005年）《神经肿瘤学杂志》73(1):57 - 69]。2006年2月举行了第二次研讨会，以回顾新的成果，并确定这种不断发展但仍然新颖的疗法中有前景的研究途径。众多国际专家在各自领域所涵盖的一般主题包括CED技术的进展、该技术的新临床应用、与CED相关的成像程序的进展、对当前或拟进行试验的综述、新药以及从实验室转向临床实践的项目的进展情况。具体主题包括新型导管的设计、用于规划的数学模型的开发、用于CED治疗中风、脊髓退行性疾病和癫痫的新型疗法、通过CED给药的基于脂质体的药物、超声驱动的CED、监测肿瘤内紫杉醇的体内效应以及其他主题。每位演讲者的报告都已连同相关参考文献一起进行了摘要整理。
