Nwagwu Chibueze D, Immidisetti Amanda V, Jiang Michael Y, Adeagbo Oluwasegun, Adamson David C, Carbonell Anne-Marie
Emory University School of Medicine, Atlanta, GA 30322, USA.
Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Pharmaceutics. 2021 Apr 15;13(4):561. doi: 10.3390/pharmaceutics13040561.
Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood-brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.
高级别胶质瘤（HGG）有效治疗方法的开发受到以下因素的阻碍：（1）血脑屏障（BBB），（2）浸润性生长模式，（3）治疗耐药性的快速发展，以及在许多情况下，（4）由于全身暴露导致的剂量限制性毒性。对流增强递送（CED）有可能通过将均匀的药物浓度直接递送至疾病部位，显著限制全身毒性并提高治疗指数。在本综述中，我们介绍了CED在高级别胶质瘤治疗中的临床经验和临床前进展。
