Ansari M Nazam, Bhandari U, Pillai K K
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110 062, India.
Indian J Exp Biol. 2006 Nov;44(11):892-7.
Ethanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. Histological examination of rat's heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic ZO extract pretreatment. The results of the present study, for the first time, provide clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant defense against ISO-induced oxidative myocardial injury in rats and exhibit cardioprotective property.
在异丙肾上腺素（ISO）处理的大鼠中，用乙醇提取的姜（ZO）提取物（200毫克/千克）预处理20天，可显著提高内源性心肌抗氧化剂（过氧化氢酶、超氧化物歧化酶和组织谷胱甘肽）的水平，降低血清标志物酶（乳酸脱氢酶、肌酸激酶、天冬氨酸转氨酶和丙氨酸转氨酶）的水平，并增加心肌脂质过氧化物。对大鼠心脏切片的组织学检查证实，给予ISO会导致心肌损伤，而用乙醇ZO提取物预处理则呈现接近正常的模式。本研究结果首次提供了明确证据，表明乙醇ZO提取物预处理可增强对ISO诱导的大鼠氧化心肌损伤的抗氧化防御，并具有心脏保护特性。
