El-Radaideh Khaled M, Al-Ghazo Mohammed A
Department of Anesthesia, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, PO Box 953, Irbid 21110, Jordan.
Saudi Med J. 2007 Jan;28(1):36-40.
To compare the conditions for laryngeal tube airway insertion obtained by the inhalation of 8% sevoflurane using a vital capacity breath (VCB) technique with propofol intravenous induction.
We carried out a prospective, randomized, single blind study at King Abdullah University Hospital, Irbid, Jordan from September 2005 to April 2006. Involved in this study were 80 adult (ASA physical status I and II) patients aged 26-70 years undergoing elective surgery under general anesthesia. The patients were randomized into 2 groups. An independent observer noted the time to loss of consciousness, the presence of adverse events, time to successful laryngeal tube placement and the number of attempts needed until a successful laryngeal tube insertion.
With the single VCB method, sevoflurane produced a loss of consciousness faster than propofol did (51.6 +/- 4.4 versus 59.7 +/- 4.9 seconds, p<0.001). The insertion of laryngeal tube was faster in the propofol group (77.2 +/- 20.2 versus 122.2 +/- 33.3 seconds, p<0.001) and required fewer attempts (1.2 +/- 0.4 versus 1.6 +/- 0.7, p<0.02). The overall incidence of complications during the induction of anesthesia as well as during the laryngeal tube insertion, especially apnea (42% versus 0%; p<0.001), was more frequent in the propofol group (82.5% versus 27.5%; p<0.001).
We conclude that vital capacity breath induction with sevoflurane produces a faster loss of consciousness and fewer side effects than propofol and efficient for laryngeal tube insertion, but takes slightly longer than propofol due to the prolonged jaw tightness.
比较采用肺活量呼吸（VCB）技术吸入8%七氟醚与丙泊酚静脉诱导用于喉罩气道插入的情况。
2005年9月至2006年4月，我们在约旦伊尔比德的阿卜杜拉国王大学医院开展了一项前瞻性、随机、单盲研究。本研究纳入80例年龄在26 - 70岁、接受全身麻醉下择期手术的成年（美国麻醉医师协会身体状况I级和II级）患者。患者被随机分为2组。一名独立观察者记录意识消失时间、不良事件的发生情况、喉罩成功置入时间以及成功插入喉罩所需的尝试次数。
采用单次VCB方法时，七氟醚使意识消失的速度比丙泊酚更快（51.6±4.4秒对59.7±4.9秒，p<0.001）。丙泊酚组喉罩插入更快（77.2±20.2秒对122.2±33.3秒，p<0.001）且所需尝试次数更少（1.2±0.4次对1.6±0.7次，p<0.02）。丙泊酚组在麻醉诱导期间以及喉罩插入期间并发症的总体发生率，尤其是呼吸暂停（42%对0%；p<0.001），更为频繁（82.5%对27.5%；p<0.001）。
我们得出结论，与丙泊酚相比，七氟醚肺活量呼吸诱导能更快地使意识消失且副作用更少，对喉罩插入有效，但由于下颌紧张时间延长，比丙泊酚稍慢。
