Topuz Derya, Postaci Aysun, Sacan Ozlem, Yildiz Nurcan, Dikmen Bayazit
Department of Anesthesiology and Reanimation, Numune Education and Research Hospital, Ankara, Turkey.
Saudi Med J. 2010 Oct;31(10):1124-9.
To compare 8% or 5% sevoflurane and propofol induction according to the ease of laryngeal mask airway (LMA) placement and hemodynamic effects in elderly patients.
Ninety unpremedicated American Society of Anesthesiologists (ASA) I-III male patients >65 years, undergoing day case urological surgical intervention under general anesthesia at the Numune Education and Research Hospital, Ankara, Turkey between October 2008 to May 2009 were studied. The patients were group into 3 and were administered intravenous (intravenous) 5 ug/kg alfentanil before induction. Patients in group propofol (P) (n=29), anesthesia was induced 1.5 mg/kg propofol intravenous; in Group 8 (n=28) and Group 5 (n=28) anesthesia was induced with 8% and 5% sevoflurane in 60% nitrous oxide, and 40% oxygen with tidal-volume-breath (TVB).
Induction times were as follows: in Group P = 54.76 +/- 12.29 sec; Group 8 = 69.93 +/- 18.76 sec, and in Group 5 = 92.14 +/- 27.68 sec (p<0.01). Apnea duration was longer in Group P (6.55 +/- 4.07 min.) than in group 8 (1.73 +/- 2.49 min), and group 5 (1.12 +/- 1.12 min) (p<0.01). The decrease in mean arterial pressure (MAP) before alfentanil (control) and after induction was significantly different between the groups.
In elderly patients who will be administered day case anesthesia, in the placement of LMA, 5 ug/kg alfentanil followed by 5% sevoflurane induction by TVB method with minimal hemodynamic changes could be an alternative to propofol induction.
根据老年患者喉罩置入的难易程度和血流动力学效应,比较8%或5%七氟醚与丙泊酚诱导效果。
选取2008年10月至2009年5月在土耳其安卡拉努穆内教育与研究医院接受全身麻醉下日间泌尿外科手术干预的90例未使用术前药、年龄>65岁的美国麻醉医师协会(ASA)I - III级男性患者进行研究。将患者分为3组,诱导前静脉注射5μg/kg阿芬太尼。丙泊酚组(P组)(n = 29),静脉注射1.5mg/kg丙泊酚诱导麻醉;8组(n = 28)和5组(n = 28)采用在60%氧化亚氮和40%氧气中以潮气量呼吸(TVB)方式分别用8%和5%七氟醚诱导麻醉。
诱导时间如下:P组 = 54.76 ± 12.29秒;8组 = 69.93 ± 18.76秒,5组 = 92.14 ± 27.68秒(p<0.01)。P组的呼吸暂停时间(6.55 ± 4.07分钟)长于8组(1.73 ± 2.49分钟)和5组(1.12 ± 1.12分钟)(p<0.01)。阿芬太尼(对照)前和诱导后平均动脉压(MAP)下降在各组间有显著差异。
对于接受日间麻醉的老年患者,在置入喉罩时,先静脉注射5μg/kg阿芬太尼,然后采用TVB法用5%七氟醚诱导,血流动力学变化最小,可作为丙泊酚诱导的替代方法。