L-抗坏血酸（维生素C）对小鼠肝微粒体中芳烃羟化酶活性的体外影响。
In vitro effects of L-ascorbic acid (vitamin C) on aryl hydrocarbon hydroxylase activity in hepatic microsomes of mice.
作者信息
Kiyohara C, Omura M, Hirohata T
机构信息
Department of Public Health, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Mutat Res. 1991 Dec;251(2):227-32. doi: 10.1016/0027-5107(91)90077-2.
When aromatic hydrocarbon (Ah)-responsive and -non-responsive strains of mice were pretreated with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), vitamin C reduced the microsomal aryl hydrocarbon hydroxylase (AHH) activity. The AHH inhibitors 7,8-benzoflavone (7,8-BF) and 3-methylsulfonyl-3',4,4',5-tetrachlorobiphenyl (3-MSF-3',4,4',5-tetraCB) showed various inhibitory effects depending upon the types of microsomes, whereas vitamin C exhibited inhibition irrespective of the types of microsomes. 7,8-BF and 3-MSF-3',4,4',5-tetraCB as well as vitamin C suppressed the reverse mutation of the Salmonella typhimurium tester strains TA98 and TA100 induced by benzo[a]pyrene.
当用3-甲基胆蒽（MC）或2,3,7,8-四氯二苯并对二恶英（TCDD）对芳烃（Ah）反应性和非反应性小鼠品系进行预处理时，维生素C可降低微粒体芳烃羟化酶（AHH）的活性。AHH抑制剂7,8-苯并黄酮（7,8-BF）和3-甲基磺酰基-3',4,4',5-四氯联苯（3-MSF-3',4,4',5-四氯联苯）根据微粒体类型显示出不同的抑制作用，而维生素C无论微粒体类型如何均表现出抑制作用。7,8-BF和3-MSF-3',4,4',5-四氯联苯以及维生素C均抑制了苯并[a]芘诱导的鼠伤寒沙门氏菌测试菌株TA98和TA100的回复突变。
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