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[给予同种异体肝细胞后肝脏中增殖和代谢过程的刺激]

[Stimulation of proliferative and metabolic processes in the liver after administration of allogeneic hepatocytes].

作者信息

Kavtiashvili K G, Gabuniia U A

出版信息

Biull Eksp Biol Med. 1991 Sep;112(9):315-7.

PMID:1720985
Abstract

The interconnection of morpho-functional changes of liver and cellular capacity to synthesize RNA and DNA in condition of the acute liver failure (ALF) and after the administration of the newborn allogenic hepatocytes (NAH) was studied by the autoradiographic method. The administration of NAH prevents, in part, the ischemic cell death and is efficient in the stimulation of the liver regeneration in ALF; it increases metabolic and proliferative activity of hepatocytes as well as of reticulo-endothelial cells.

摘要

采用放射自显影法研究了急性肝衰竭(ALF)状态下及给予新生同种异体肝细胞(NAH)后肝脏形态功能变化与细胞合成RNA和DNA能力之间的相互关系。给予NAH可部分预防缺血性细胞死亡,并有效刺激ALF中的肝脏再生;它可增加肝细胞以及网状内皮细胞的代谢和增殖活性。

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