Nisimaru N, Okahara K, Nagao S
Department of Physiology, Medical College of Oita, Japan.
Neurosci Res. 1991 Oct;12(1):240-50. doi: 10.1016/0168-0102(91)90114-e.
Climbing fiber responses were evoked in the medial vermal cortex of lobule VIIa by stimulation of the contralateral medial accessory olive (MAO) in anesthetized, paralyzed rabbits. Effective stimulating sites were localized in a small medial part of the caudal MAO, at 0.4-1.6 mm rostral from the caudal pole of the MAO (total length of the MAO, 4.2 mm). Stimulation of this MAO area induced depression in renal sympathetic nerve activity and this depressant response disappeared after ablation of lobule VIIa. Following injections of horseradish peroxidase into the small areas of lobule VIb, VIc, VIIa or VIIb, retrogradely labeled cells were found in corresponding small particular regions of the MAO: lobule VIb to the most caudal part, lobule VIc to the next caudal, lobule VIIa to the most rostral within the caudal MAO, and lobule VIIb further rostrally to the intermediate MAO. There was a clear disparity between the medial halves of lobules VI and VII projected from the medial MAO and the lateral halves from the lateral MAO. These results show that climbing fiber projections to lobules VI and VII are topographically organized, and that the medial region of lobule VIIa, related to cardiovascular function, receives climbing fibers from a localized small medial region of the caudal MAO.
在麻醉、麻痹的兔中，通过刺激对侧内侧副橄榄核（MAO），在小叶VIIa的内侧蚓部皮质诱发了攀爬纤维反应。有效的刺激部位位于尾侧MAO的内侧小区域，距MAO尾极头端0.4 - 1.6毫米处（MAO全长4.2毫米）。刺激该MAO区域可导致肾交感神经活动抑制，且在切除小叶VIIa后这种抑制反应消失。将辣根过氧化物酶注射到小叶VIb、VIc、VIIa或VIIb的小区域后，在MAO相应的特定小区域发现了逆行标记的细胞：小叶VIb对应最尾侧部分，小叶VIc对应次尾侧部分，小叶VIIa对应尾侧MAO内最头端部分，小叶VIIb更向头端对应中间MAO部分。从内侧MAO投射到小叶VI和VII内侧半区的纤维与从外侧MAO投射到外侧半区的纤维之间存在明显差异。这些结果表明，向小叶VI和VII的攀爬纤维投射是按拓扑结构组织的，且与心血管功能相关的小叶VIIa内侧区域从尾侧MAO的局部小内侧区域接收攀爬纤维。
