Tsujimoto Masaki, Yabutani Tomoki, Sano Atsushi, Tani Yuji, Murotani Hiroki, Mishima Yuji, Maruyama Kenichi, Yasuzawa Mikito, Motonaka Junko
Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima, Japan.
Anal Sci. 2007 Jan;23(1):59-63. doi: 10.2116/analsci.23.59.
A glucose sensor was developed by electrocopolymerization using pyrroles containing a tris-bipyridine (bpy) osmium complex (Os-py), pyrrole (py), pyrrole propanoic acid (PPA) and glucose oxidase (GOx) to improve the key performance characteristics, such as the sensitivity, selectivity, and long-term stability. Tris-bipyridine osmium pyrrole complexes with four different methylene moieties were utilized to correlate the methylene length with the glucose sensor performance. The electrocatalytic response of glucose was clearly observed at electrodes modified with Os-py, except for the electrode immobilized with the Os-py complex containing the shortest methylene moiety. The current response to glucose increased up to a concentration of 100 mmol dm(-3). The electrocatalytic response to glucose at the Os(bpy)(2)(py(6)-bpy)/py/PPA/GOx electrode was stable for more than 100 days. Dissolved oxygen and potential interference compounds (ascorbic acid, uric acid, and acetaminophen) minimally perturbed the current response to glucose at the Os(DM-bpy)(2)(py(6)-bpy)/py/PPA/GOx electrode. Based on these results, a longer methylene moiety appears to improve the performance characteristics of a glucose sensor fabricated via the electropolymerization of tris-bipyridine osmium pyrrole complexes.
通过电共聚，使用含有三联吡啶（bpy）锇配合物（Os-py）的吡咯、吡咯（py）、吡咯丙酸（PPA）和葡萄糖氧化酶（GOx）开发了一种葡萄糖传感器，以改善其关键性能特征，如灵敏度、选择性和长期稳定性。利用具有四个不同亚甲基部分的三联吡啶锇吡咯配合物来关联亚甲基长度与葡萄糖传感器性能。除了固定有含最短亚甲基部分的Os-py配合物的电极外，在用Os-py修饰的电极上清楚地观察到了葡萄糖的电催化响应。对葡萄糖的电流响应在浓度高达100 mmol dm(-3)时增加。Os(bpy)(2)(py(6)-bpy)/py/PPA/GOx电极对葡萄糖的电催化响应稳定超过100天。溶解氧和潜在干扰化合物（抗坏血酸、尿酸和对乙酰氨基酚）对Os(DM-bpy)(2)(py(6)-bpy)/py/PPA/GOx电极上葡萄糖的电流响应干扰最小。基于这些结果来看，更长的亚甲基部分似乎能改善通过三联吡啶锇吡咯配合物电聚合制备的葡萄糖传感器的性能特征。
