Wang You, Xu Hui, Zhang Jianming, Li Guang
State Key Laboratory of Industrial Control Technology, Institute of Advanced Process Control, Zhejiang University, Hangzhou 310027, P.R. China.
Sensors (Basel). 2008 Mar 27;8(4):2043-2081. doi: 10.3390/s8042043.
Demanded by modern medical diagnosis, advances in microfabrication technology have led to the development of fast, sensitive and selective electrochemical sensors for clinic analysis. This review addresses the principles behind electrochemical sensor design and fabrication, and introduces recent progress in the application of electrochemical sensors to analysis of clinical chemicals such as blood gases, electrolytes, metabolites, DNA and antibodies, including basic and applied research. Miniaturized commercial electrochemical biosensors will form the basis of inexpensive and easy to use devices for acquiring chemical information to bring sophisticated analytical capabilities to the non-specialist and general public alike in the future.
受现代医学诊断的需求推动，微纳制造技术的进步促使了用于临床分析的快速、灵敏且选择性高的电化学传感器的发展。本文综述了电化学传感器设计与制造背后的原理，并介绍了电化学传感器在分析临床化学物质（如血气、电解质、代谢物、DNA和抗体）方面的最新进展，包括基础研究和应用研究。小型化的商业电化学生物传感器将成为未来价格低廉且易于使用的设备的基础，这些设备能够获取化学信息，为非专业人士和普通大众带来先进的分析能力。
