Teshima Kenji, Asano Kazushi, Iwanaga Koji, Koie Hiroshi, Uechi Masami, Kato Yuka, Kutara Kenji, Edamura Kazuya, Hasegawa Atsuhiko, Tanaka Shigeo
Laboratory of Veterinary Surgery, College of Bioresource Sciences, Nihon University, Fujisawa, Japan.
J Vet Med Sci. 2006 Dec;68(12):1307-13. doi: 10.1292/jvms.68.1307.
Right ventricular (RV) Tei index (index of myocardial performance) has been demonstrated to be clinically useful in estimating RV function in various human cardiac diseases. The purposes of this study were to validate the correlation between RV Tei index and RV function obtained by cardiac catheterization in healthy dogs, and to evaluate the RV Tei index in dogs with tricuspid regurgitation (TR). In healthy dogs, the RV Tei index significantly correlated with the RV peak +dP/dt (r=-0.80, p<0.0001) and -dP/dt (r=0.69, p=0.0001). In normal dogs, the RV Tei index was not significantly correlated with heart rate, body weight, and age. The RV Tei index significantly increased in dogs with moderate to severe TR (0.39 +/- 0.35, p=0.0015), filariasis (0.46 +/- 0.16, p=0.0131), and trivial to mild TR and severe mitral regurgitation (MR; 0.61 +/- 0.14, p=0.0017) when compared with the normal dogs (0.17 +/- 0.10). In addition, the RV Tei index in dogs with TR significantly increased in association with pulmonary hypertension [PH(-), 0.19 +/- 0.09; PH(+), 0.65 +/- 0.14; respectively p<0.0001]. Our study has demonstrated that RV Tei index is a feasible approach to estimate RV function in dogs and is not influenced by heart rate, body weight, and aging. Further investigations are required to clarify the clinical significance of RV Tei index in dogs with right-sided cardiac diseases.
右心室（RV）Tei指数（心肌性能指数）已被证明在评估各种人类心脏疾病中的右心室功能方面具有临床实用性。本研究的目的是验证健康犬中RV Tei指数与通过心导管检查获得的右心室功能之间的相关性，并评估患有三尖瓣反流（TR）的犬的RV Tei指数。在健康犬中，RV Tei指数与右心室峰值 +dP/dt（r = -0.80，p < 0.0001）和 -dP/dt（r = 0.69，p = 0.0001）显著相关。在正常犬中，RV Tei指数与心率、体重和年龄无显著相关性。与正常犬（0.17 ± 0.10）相比，中度至重度TR犬（0.39 ± 0.35，p = 0.0015）、丝虫病犬（0.46 ± 0.16，p = 0.0131）以及轻度至中度TR和重度二尖瓣反流（MR）犬（0.61 ± 0.14，p = 0.0017）的RV Tei指数显著升高。此外，患有TR的犬的RV Tei指数随着肺动脉高压[PH(-)，0.19 ± 0.09；PH(+)，0.65 ± 0.14；分别为p < 0.0001]而显著升高。我们的研究表明，RV Tei指数是评估犬右心室功能的一种可行方法，且不受心率、体重和年龄的影响。需要进一步研究以阐明RV Tei指数在患有右侧心脏疾病的犬中的临床意义。
