Teshima Kenji, Asano Kazushi, Iwanaga Koji, Koie Hiroshi, Uechi Masami, Kato Yuka, Kutara Kenji, Kanno Nobuyuki, Seki Mamiko, Edamura Kazuya, Hasegawa Atsuhiko, Tanaka Shigeo
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
J Vet Med Sci. 2007 Feb;69(2):117-23. doi: 10.1292/jvms.69.117.
The left ventricular (LV) Tei index (index of myocardial performance) has been demonstrated to be clinically useful in estimating comprehensive LV function, including the systolic and diastolic performances, in various human cardiac diseases. The purposes of this study were to validate the correlation between the LV Tei index and LV function obtained by cardiac catheterization in healthy dogs, and to evaluate the LV Tei index in dogs with naturally occurring mitral regurgitation (MR). In healthy dogs, the LV Tei index was significantly correlated with the LV peak +dP/dt (r = -0.89) and LV peak -dP/dt (r=0.87). The LV Tei index significantly increased in dogs with MR compared with normal dogs and significantly increased with progressively more severe clinical signs due to heart failure. The elevation of the LV Tei index in dogs with symptomatic MR appears to be associated with shortening of ejection time. The LV Tei index significantly increased with age and was not correlated with heart rate and body weight in normal dogs. In conclusion, our study demonstrated that the LV Tei index was measurable in dogs and not influenced by heart rate and body weight. The LV Tei index significantly increased with the progression of clinical signs in MR dogs. In particular, the elevation of the LV Tei index in dogs with symptomatic MR due to shortening of ejection time may suggest LV systolic dysfunction and the decrement of forward stroke volume.
左心室（LV）Tei指数（心肌性能指数）已被证明在评估各种人类心脏疾病的综合左心室功能（包括收缩和舒张性能）方面具有临床实用性。本研究的目的是验证健康犬中LV Tei指数与通过心导管检查获得的左心室功能之间的相关性，并评估自然发生二尖瓣反流（MR）的犬的LV Tei指数。在健康犬中，LV Tei指数与左心室峰值 +dP/dt（r = -0.89）和左心室峰值 -dP/dt（r = 0.87）显著相关。与正常犬相比，患有MR的犬的LV Tei指数显著升高，并且随着因心力衰竭导致的临床症状逐渐加重而显著增加。有症状的MR犬的LV Tei指数升高似乎与射血时间缩短有关。在正常犬中，LV Tei指数随年龄显著增加，且与心率和体重无关。总之，我们的研究表明LV Tei指数在犬中是可测量的，且不受心率和体重的影响。在患有MR的犬中，LV Tei指数随着临床症状的进展而显著增加。特别是，有症状的MR犬由于射血时间缩短导致的LV Tei指数升高可能提示左心室收缩功能障碍和前向搏出量减少。
