Hogan Alexandra M, Butterfield Elinor L, Phillips Luke, Hadwin Julie A
University of Southampton, Highfield, UK.
J Cogn Neurosci. 2007 Jan;19(1):25-31. doi: 10.1162/jocn.2007.19.1.25.
The behavioral inhibition system [Gray, J. A. The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Oxford: Oxford University Press, 1982] proposes that anxiety is associated with the processing of novel stimuli. We aimed to explore this relationship by recording auditory event-related potentials associated with unexpected novel noises in typically developing children. Children aged 10-14 years with low (n = 12) and high (n = 11) self-report trait anxiety were assessed using a novelty oddball task. The N1 associated with novel stimuli, specifically the "N1c" component maximal at temporal lobe sites, was of significantly longer latency (p = .014) and greater amplitude (p = .004) in the high compared with the low anxious group. This group difference was supported by linear correlations between N1c amplitude and trait anxiety scores. There was no effect of anxiety on the later novelty P3. These data suggest a subtle moderating role of trait anxiety on brain response to novelty, and further research with clinically anxious children is indicated.
行为抑制系统[格雷，J. A.《焦虑的神经心理学：对隔区 - 海马系统功能的探究》。牛津：牛津大学出版社，1982年]提出，焦虑与新异刺激的处理有关。我们旨在通过记录与正常发育儿童中意外新异噪音相关的听觉事件相关电位来探究这种关系。使用新异oddball任务对10 - 14岁自我报告特质焦虑程度低（n = 12）和高（n = 11）的儿童进行评估。与新异刺激相关的N1，特别是在颞叶部位最大的“N1c”成分，与低焦虑组相比，高焦虑组的潜伏期显著更长（p = 0.014）且波幅更大（p = 0.004）。N1c波幅与特质焦虑得分之间的线性相关性支持了这一组间差异。焦虑对后期的新异P3没有影响。这些数据表明特质焦虑对大脑对新异性的反应有微妙的调节作用，并表明需要对临床焦虑儿童进行进一步研究。
