Falkensammer B, Duftner C, Seiler R, Pavlic M, Walder G, Wilflingseder D, Stoiber H, Klein-Weigel P, Dierich M, Fraedrich G, Würzner R, Schirmer M
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz-Pregl-Strasse 3, 6020, Innsbruck, Austria.
Eur J Clin Microbiol Infect Dis. 2007 Feb;26(2):141-5. doi: 10.1007/s10096-006-0245-5.
In a case-control study that included a total of 98 patients and 83 controls, the possible link between various pathogens and abdominal aortic aneurysms was investigated. For 68 patients with abdominal aortic aneurysm and age-matched controls, no differences were detected in the levels of immunoglobulin (Ig)A and IgG Chlamydiaceae and Chlamydophila pneumoniae antibodies. Patients with IgA titers positive for Chlamydophila pneumoniae showed progressive disease (defined as an annual increase of the aneurysm diameter of > or = 0.5 cm) more frequently than patients with negative IgA titers (p = 0.046). Polymerase chain reactions performed to detect DNA for Chlamydophila pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, human cytomegalovirus, Borrelia burgdorferi and Helicobacter pylori in tissue specimens of 30 patients and 15 controls were negative. In summary, Chlamydophila pneumoniae may contribute to aortic aneurysm disease progression, but DNA of this and other pathogens was not found in patients' specimens.
在一项总共纳入98例患者和83名对照的病例对照研究中，调查了各种病原体与腹主动脉瘤之间的可能联系。对于68例腹主动脉瘤患者及年龄匹配的对照，未检测到免疫球蛋白（Ig）A和IgG嗜衣原体和肺炎嗜衣原体抗体水平存在差异。肺炎嗜衣原体IgA滴度呈阳性的患者比IgA滴度呈阴性的患者更频繁地出现疾病进展（定义为动脉瘤直径每年增加≥0.5 cm）（p = 0.046）。对30例患者和15名对照的组织标本进行聚合酶链反应以检测肺炎嗜衣原体、沙眼衣原体、鹦鹉热嗜衣原体、人巨细胞病毒、伯氏疏螺旋体和幽门螺杆菌的DNA，结果均为阴性。总之，肺炎嗜衣原体可能促进主动脉瘤疾病进展，但在患者标本中未发现该病原体及其他病原体的DNA。
