Karlsson L, Gnarpe J, Nääs J, Olsson G, Lindholm J, Steen B, Gnarpe H
Gävle-Sandviken Central Hospital, Gävle, Sweden.
Eur J Vasc Endovasc Surg. 2000 Jun;19(6):630-5. doi: 10.1053/ejvs.1999.1057.
to investigate the presence of Chlamydia pneumoniae in the wall of abdominal aortic aneurysms (AAAs) and in the aortas of patients without a history of cardiovascular disease.
case-control study.
twenty-six consecutive patients operated for AAA were compared to 17 controls.
aorta was obtained at surgery or autopsy (controls) and prepared for immunohistochemical (IHC) analysis and culture for C. pneumoniae. Throat swabs from 14/26 patients were analysed by PCR for C. pneumoniae. Blood was obtained from 24/26 patients and from 178 70-year-old males.
C. pneumoniae was detected in the aortic aneurysms of 20/26 patients by IHC. C. pneumoniae was cultured from 10 of the 20 IHC-positive patients. Only 1/17 controls was positive for C. pneumoniae by IHC (p=0.0001). PCR was positive for C. pneumoniae in 5/14 patients. Serological analysis by microimmunofluoresence (MIF) showed significantly more high titres of the specific antibodies to C. pneumoniae in patients than in age-matched male controls.
we conclude that C. pneumoniae is often present in AAAs in a viable form and that C. pneumoniae is linked to the pathogenesis of AAA.
研究腹主动脉瘤（AAA）壁以及无心血管疾病病史患者的主动脉中肺炎衣原体的存在情况。
病例对照研究。
将连续26例接受AAA手术的患者与17例对照进行比较。
在手术或尸检（对照组）时获取主动脉，准备进行肺炎衣原体的免疫组织化学（IHC）分析和培养。对14/26例患者的咽拭子进行肺炎衣原体的PCR分析。从24/26例患者以及178名70岁男性中采集血液。
通过IHC在20/26例患者的主动脉瘤中检测到肺炎衣原体。在20例IHC阳性患者中的10例培养出肺炎衣原体。仅1/17例对照通过IHC检测为肺炎衣原体阳性（p = 0.0001）。5/14例患者的PCR检测肺炎衣原体呈阳性。通过微量免疫荧光（MIF）进行的血清学分析显示，患者中针对肺炎衣原体的特异性抗体高滴度显著多于年龄匹配的男性对照。
我们得出结论，肺炎衣原体常以存活形式存在于AAA中，且肺炎衣原体与AAA的发病机制有关。
