Annambhotla Suman, Bourgeois Sebastian, Wang Xinwen, Lin Peter H, Yao Qizhi, Chen Changyi
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA.
World J Surg. 2008 Jun;32(6):976-86. doi: 10.1007/s00268-007-9456-x.
Abdominal aortic aneurysm (AAA) is an increasingly common clinical condition with fatal implications. It is associated with advanced age, male gender, cigarette smoking, atherosclerosis, hypertension, and genetic predisposition. Although significant evidence has emerged in the last decade, the molecular mechanisms of AAA formation remain poorly understood. Currently, the treatment for AAA remains primarily surgical with the lone innovation of endovascular therapy. With advances in the human genome, understanding precisely which molecules and genes mediate AAA development and blocking their activity at the molecular level could lead to important new discoveries and therapies. This review summarizes recent updates in molecular mechanisms of AAA formation, including animal models, autoimmune components, infection, key molecules and cytokines, mechanical forces, genetics, and pharmacotherapy. This review will be helpful to those who want to recognize the newest endeavors within the field and identify possible lines of investigation in AAA.
腹主动脉瘤（AAA）是一种临床中越来越常见且具有致命影响的疾病。它与高龄、男性、吸烟、动脉粥样硬化、高血压以及遗传易感性有关。尽管在过去十年中已经出现了大量证据，但腹主动脉瘤形成的分子机制仍知之甚少。目前，腹主动脉瘤的治疗主要仍是手术治疗，血管内治疗是唯一的创新方法。随着人类基因组学的进展，精确了解哪些分子和基因介导腹主动脉瘤的发展，并在分子水平上阻断它们的活性，可能会带来重要的新发现和治疗方法。这篇综述总结了腹主动脉瘤形成分子机制的最新进展，包括动物模型、自身免疫成分、感染、关键分子和细胞因子、机械力、遗传学和药物治疗。这篇综述将有助于那些想要了解该领域最新进展并确定腹主动脉瘤可能研究方向的人。
