唐氏综合征与母亲年龄：随时间的变化及危险因素综述

Down syndrome and maternal age: changes over time and review of risk factors.

作者信息

Hashishe M M

机构信息

Department of Human Genetics, Medical Research Institute, Alexandria University.

出版信息

J Egypt Public Health Assoc. 1997;72(3-4):325-43.

PMID:17216992

Abstract

During 1987-1996, 292 Egyptian Down syndrome (Trisomy 21) infants were identified in Human Genetics Department in Alexandria. They comprised 139 males and 153 females (sex ratio 0.91). Data on maternal age, paternal age and birth order were analyzed. Maternal ages were examined for transient changes over time and for linear trends. Significant changes in maternal age over the 10 years period of study were observed. First born infants were at greater risk of trisomy 21 than higher order of births, independent of maternal age.

摘要

1987年至1996年期间，亚历山大市人类遗传学部门共鉴定出292例埃及唐氏综合征（21 - 三体综合征）婴儿。其中男性139例，女性153例（性别比为0.91）。对产妇年龄、父亲年龄和出生顺序的数据进行了分析。研究了产妇年龄随时间的短暂变化和线性趋势。在为期10年的研究期间，观察到产妇年龄有显著变化。与较高出生顺序的婴儿相比，头胎婴儿患21 - 三体综合征的风险更高，且与产妇年龄无关。