McConnell M J, Licht J D
Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, 303 E Superior St, Chicago, IL 60611, USA.
Curr Top Microbiol Immunol. 2007;313:31-48. doi: 10.1007/978-3-540-34594-7_3.
The PLZF gene is one of five partners fused to the retinoic acid receptor alpha in acute promyelocytic leukemia. PLZF encodes a DNA-binding transcriptional repressor and the PLZF-RARalpha fusion protein like other RARalpha fusions can inhibit the genetic program mediated by the wild tpe retinoic acid receptor. However an increasing body of literature indicates an important role for the PLZF gene in growth control and development. This information suggests that loss of PLZF function might also contribute to leukemogenesis.
PLZF基因是急性早幼粒细胞白血病中与维甲酸受体α融合的五个伙伴基因之一。PLZF编码一种DNA结合转录抑制因子，并且PLZF-RARα融合蛋白与其他RARα融合蛋白一样，能够抑制由野生型维甲酸受体介导的遗传程序。然而，越来越多的文献表明PLZF基因在生长控制和发育中具有重要作用。这一信息提示PLZF功能的丧失可能也与白血病发生有关。
